Angoline hydrochloride

Research use only, not for human use.

Angoline hydrochloride (6-Methoxyldihydrochelerythrine) is an IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum with anticancer activity and inhibits STAT3 signaling.

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.

Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively.Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3.Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation.Western Blot Analysis Cell Line:HepG2/STAT3 cell lines Concentration:0, 1, 10, 30 and 100 μM Incubation Time:2 hours Result:Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.Western Blot Analysis Cell Line:MDA-MB-231, H4 and HepG2 cell lines Concentration:0-100 μM Incubation Time:72 hours Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.

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Apoptosis

IL Receptor

IL Receptor | STAT

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1071676-04-4

415.87

C22H22ClNO5

>98% (HPLC)

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Cl.O(C=1C=CC=2C3=CC=C4C=C5OCOC5=CC4=C3N(C)C(OC)C2C1OC)C

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(-20℃)

With Ice Pack

≥ 2 years